Brand  (β version)

PDB ID: 1OKY

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Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
SO4 Sulfate ion PoSSuM
STU Staurosporine PoSSuM
Non-standard Residues
Code Name Show
SEP Phosphoserine
Glycosylation
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Structure summary

Code : 1OKY   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Structure of human PDK1 kinase domain in complex with staurosporine
Release Data : 2004-07-29
Compound :
mol_id molecule chains synonym
1 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1 A HPDK1
ec: 2.7.1.37
fragment: KINASE DOMAIN, RESIDUES 51-360
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
cell_line: SF21
expression_system_cell_line: Sf21
expression_system_vector_type: BACULOVIRUS
expression_system_plasmid: PFASTBAC1
other_details: BACULOVIRUS INFECTED
Authors : Komander, D., Kular, G.S., Alessi, D.R., Van Aalten, D.M.F.
Keywords : PROTEIN KINASE, PKB, PDK1, STAUROSPORINE, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Structural Basis for Ucn-01 (7-Hydroxystaurosporine) Specificity and Pdk1 (3-Phosphoinositide-Dependent Protein Kinase-1) Inhibition

Komander, D.,Kular, G.S.,Bain, J.  et al.
(2003)  Biochem.J.  375 : 255

PubMed: 12892559
DOI: 10.1042/BJ20031119

Reaction

Chain : A
UniProt : O15530 (PDPK1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 -
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 -
-