Brand  (β version)

PDB ID: 1OF6

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Ligands
Code Name Style Show Link
MN Manganese (II) ion PoSSuM
DTY D-tyrosine PoSSuM
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Structure summary

Code : 1OF6   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : crystal structure of the tyrosine-regulated 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from saccharomyces cerevisiae complexed with tyrosine and manganese
Release Data : 2004-05-06
Compound :
mol_id molecule chains synonym
1 PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED A,B,C,D,E,F,G,H PHOSPHO-2-KETO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE, 3-DEOXY-D-ARABINO-HEPTULOSONATE 7-PHOSPHATE SYNTHASE, PHOSPHO-2-DEHYDRO- 3-DEOXYHEPTONATE ALDOLASE
ec: 4.1.2.15
Source :
mol_id organism_scientific organism_common expression_system
1 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST SACCHAROMYCES CEREVISIAE  (taxid:4932)
strain: RH1326
Authors : Koenig, V., Pfeil, A., Heinrich, G., Braus, G., Schneider, T.R.
Keywords : BETA-ALPHA-BARREL, LYASE, SYNTHASE, ALDOLASE, SYNTHETASE
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Crystal Structure of the Double Complex of the Tyrosine Sensitive Dahp Synthase from Yeast

Koenig, V.,Pfeil, A.,Heinrich, G.  et al.
To be Published 

Evolution of Feedback-Inhibited Beta /Alpha Barrel Isoenzymes by Gene Duplication and a Single Mutation.

Hartmann, M.,Schneider, T.R.,Pfeil, A.  et al.
(2003)  Proc.Natl.Acad.Sci.USA  100 : 862

PubMed: 12540830
DOI: 10.1073/PNAS.0337566100

Reaction

Chain : A, B, C, D, E, F, G, H
UniProt : P32449 (AROG_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7- phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate 2.5.1.54 -
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