Het-PDB Navi2 (PDB: 1OE0)

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Ligands
Code	Name		Style	Show	Link
TTP	Thymidine-5'-triphosphate				PoSSuM
MG	Magnesium ion				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1OE0

Code :

1OE0 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

CRYSTAL STRUCTURE OF DROSOPHILA DEOXYRIBONUCLEOSIDE KINASE IN COMPLEX WITH DTTP

Release Data :

2003-10-23

Compound :

mol_id	molecule	chains
1	DEOXYRIBONUCLEOSIDE KINASE	A,B,C,D
	ec: 2.7.1.145 fragment: TRUNCATION MUTANT, RESIDUES 1-230

Source :

mol_id	organism_scientific	organism_common	expression_system
1	DROSOPHILA MELANOGASTER (taxid:7227)	FRUIT FLY	ESCHERICHIA COLI (taxid:511693)
	expression_system_strain: BL21

Authors :

Mikkelsen, N.E., Johansson, K., Karlsson, A., Knecht, W., Andersen, G., Piskur, J., Munch-Petersen, B., Eklund, H.

Keywords :

TRANSFERASE, DROSOPHILA, DEOXYRIBONUCLEOSIDE KINASE, DTTP, COMPLEX, FEEDBACK INHIBITION, SALVAGE PATHWAY

Exp. method :

X-RAY DIFFRACTION ( 2.40 Å )

Citation :

Structural Basis for Feedback Inhibition of the Deoxyribonucleoside Salvage Pathway:Studies of the Drosophila Deoxyribonucleoside Kinase

Mikkelsen, N.E.,Johansson, K.,Karlsson, A. et al.
(2003) Biochemistry 42 : 5706

Chain :

A, B, C, D

UniProt :

Q9XZT6 (DNK_DROME)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a 2'-deoxyribonucleoside + ATP = a 2'-deoxyribonucleoside 5'- phosphate + ADP + H(+)	2.7.1.145	PubMed:10446143, PubMed:10692477, PubMed:16008571, PubMed:9461577
	-

PDB ID: 1OE0