PDB ID: 1ODW
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|Code :||1ODW PDBj RCSB PDB PDBe|
|Header :||Hydrolase/Hydrolase Inhibitor|
|Title :||Native HIV-1 Proteinase|
|Release Data :||1997-04-01|
|Authors :||Thanki, N., Kervinen, J., Wlodawer, A.|
|Keywords :||PROTEINASE, RETROPEPSIN, RETROVIRUS, HIV, Hydrolase-Hydrolase Inhibitor complex|
|Exp. method :||X-RAY DIFFRACTION ( 2.1 Å )|
Structural Analysis of the Native and Drug-Resistant HIV-1 Proteinases Complexed with an Aminodiol Inhibitor
Kervinen, J.,Thanki, N.,Zdanov, A.
|Chain :||A, B|
|UniProt :||P04585 (POL_HV1H2)|
|Reaction :||Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro.
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).