Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
MG Magnesium ion
ENX Enacyloxin iia
GNP Phosphoaminophosphonic acid-guanylate ester
Modified Residues
Code Name Link
YG Wybutosine
1MA 6-hydro-1-methyladenosine-5'-monophosphate
2MG 2n-methylguanosine-5'-monophosphate
5MC 5-methylcytidine-5'-monophosphate
5MU 5-methyluridine 5'-monophosphate
7MG 7n-methyl-8-hydroguanosine-5'-monophosphate
H2U 5,6-dihydrouridine-5'-monophosphate
M2G N2-dimethylguanosine-5'-monophosphate
OMC O2'-methylycytidine-5'-monophosphate
OMG O2'-methylguanosine-5'-monophosphate
PHA Phenylalaninal
PSU Pseudouridine-5'-monophosphate
Code : 1OB5
Header : HYDROLASE
Title : T. aquaticus elongation factor EF-Tu complexed with the antibiotic enacyloxin IIa, a GTP analog, and Phe-tRNA
Release Data : 2005-10-13
Compound :
mol_id molecule chains synonym
1 ELONGATION FACTOR TU A,C,E EF-TU
ec: 3.6.1.48
mol_id molecule chains
2 TRANSFER-RNA, PHE B,D,F
other_details: AMINO-ACYLATED (PHE) AT THE 3' END
Source :
mol_id organism_scientific expression_system
1 THERMUS AQUATICUS  (taxid:271) ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
other_details: TUF-A GENE
mol_id organism_scientific organism_common
2 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
other_details: SIGMA-ALDRICH COMPOUND
Authors : Dahlberg, C., Nielsen, R.C., Parmeggiani, A., Nyborg, J., Nissen, P.
Keywords : HYDROLASE, GTPASE, TRANSLATION ELONGATION FACTOR, TRANSFER RNA, GTP-BINDING, NUCLEOTIDE-BINDING, PROTEIN BIOSYNTHESIS
Exp. method : X-RAY DIFFRACTION ( 3.10 Å )
Citation :

Enacyloxin Iia Pinpoints a Binding Pocket of Elongation Factor TU for Development of Novel Antibiotics.

Parmeggiani, A.,Krab, I.M.,Watanabe, T.  et al.
(2006)  J.Biol.Chem.  281 : 2893

PubMed: 16257965
DOI: 10.1074/JBC.M505951200

Chain : A, C, E
UniProt : Q01698 (EFTU_THEAQ)
Reaction : -