Het-PDB Navi2 (PDB: 1O5G)

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Color scheme of protein:

Ligands
Code	Name	Link
CA	Calcium ion	PoSSuM
CR9	2-{5-[amino(iminio)methyl]-6-fluoro-1h-benzimidazol-2-yl}-6-[(2-methylcyclohexyl)oxy]benzenolate	PoSSuM
NA	Sodium ion	PoSSuM

Non-standard Residues
Code	Name	Show
TYS	O-sulfo-L-tyrosine

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 1O5G

Code :

1O5G PDBj RCSB PDB PDBe

Header :

BLOOD CLOTTING,HYDROLASE/INHIBITOR

Title :

Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)

Release Data :

2004-09-21

Compound :

mol_id	molecule	chains	synonym
1	Prothrombin	L	Coagulation factor II
	ec: 3.4.21.5 fragment: LIGHT CHAIN, RESIDUES 328-363

mol_id	molecule	chains	synonym
2	Prothrombin	H	Coagulation factor II
	ec: 3.4.21.5 fragment: HEAVY CHAIN, RESIDUES 364-620

mol_id	molecule	chains
3	Hirudin IIIB'	I

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human

mol_id	organism_scientific
3	Hirudo medicinalis (taxid:6421)
	synthetic: yes

Authors :

Katz, B.A., Luong, C., Ho, J.D., Somoza, J.R., Gjerstad, E., Tang, J., Williams, S.R., Verner, E., Mackman, R.L., Young, W.B., Sprengeler, P.A., Chan, H., Mortara, K., Janc, J.W., McGrath, M.E.

Keywords :

Ala190 uPA, S1 site, selectivity, conserved water displacement hydrogen bond deficit, trypsin, thrombin, hepsin, factor VIIa, BLOOD CLOTTING, hydrolase, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, HYDROLASE-INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.75 Å )

Citation :

Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).

Katz, B.A.,Luong, C.,Ho, J.D. et al.
(2004) J.Mol.Biol. 344 : 527 - 547

PubMed: 15522303
DOI: 10.1016/j.jmb.2004.09.032

Chain :

UniProt :

P00734 (THRB_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.	3.4.21.5	-
	-	-

Chain :	I
UniProt :	P28511 (HIR3C_HIRME)
Reaction :	-

PDB ID: 1O5G

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