Het-PDB Navi2 (PDB: 1O5F)

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Ligands
Code	Name		Style	Show	Link
CR9	2-{5-[amino(iminio)methyl]-6-fluoro-1h-benzimidazol-2-yl}-6-[(2-methylcyclohexyl)oxy]benzenolate				PoSSuM

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Download interaction data: 1O5F

Code :

1O5F PDBj RCSB PDB PDBe

Header :

serine protease, hydrolase

Title :

Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)

Release Data :

2004-09-21

Compound :

mol_id	molecule	chains	synonym
1	Serine protease hepsin	L	Transmembrane protease, serine 1
	ec: 3.4.21.- fragment: light chain mutation: N67A

mol_id	molecule	chains	synonym
2	Serine protease hepsin	H	Transmembrane protease, serine 1
	ec: 3.4.21.- fragment: heavy chain (catalytic domain)

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Pichia pastoris (taxid:4922)
	gene: HPN OR TMPRSS1 expression_system_variant: KM71

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Pichia pastoris (taxid:4922)
	gene: HPN OR TMPRSS1 expression_system_variant: KM71

Authors :

Katz, B.A., Luong, C., Ho, J.D., Somoza, J.R., Gjerstad, E., Tang, J., Williams, S.R., Verner, E., Mackman, R.L., Young, W.B., Sprengeler, P.A., Chan, H., Mortara, K., Janc, J.W., McGrath, M.E.

Keywords :

srcr, scavenger receptor cysteine-rich domain, serine protease Ala190 uPA, S1 site, selectivity, conserved water displacement hydrogen bond deficit, trypsin, thrombin, hepsin, factor VIIa, serine protease, hydrolase

Exp. method :

X-RAY DIFFRACTION ( 1.78 Å )

Citation :

Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).

Katz, B.A.,Luong, C.,Ho, J.D. et al.
(2004) J.Mol.Biol. 344 : 527 - 547

PubMed: 15522303
DOI: 10.1016/j.jmb.2004.09.032

PDB ID: 1O5F

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