Het-PDB Navi2 (PDB: 1O5D)

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Ligands
Code	Name		Style	Show	Link
CR9	2-{5-[amino(iminio)methyl]-6-fluoro-1h-benzimidazol-2-yl}-6-[(2-methylcyclohexyl)oxy]benzenolate				PoSSuM

Non-standard Residues
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Download interaction data: 1O5D

Code :

1O5D PDBj RCSB PDB PDBe

Header :

BLOOD CLOTTING, hydrolase

Title :

Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)

Release Data :

2004-09-21

Compound :

mol_id	molecule	chains	synonym
1	Coagulation factor VII	L	Serum prothrombin conversion accelerator, Eptacog alfa
	ec: 3.4.21.21 fragment: light chain

mol_id	molecule	chains	synonym
2	Coagulation factor VII	H	Serum prothrombin conversion accelerator, Eptacog alfa
	ec: 3.4.21.21 fragment: heavy chain (catalytic domain)

mol_id	molecule	chains	synonym
3	Tissue factor	T	TF, Coagulation factor III, Thromboplastin, CD142 antigen
	mutation: residues 2-219

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Homo sapiens (taxid:9606)
	gene: F7 expression_system_common: Human expression_system_cell_line: 293 expression_system_organ: embryonic kidney expression_system_vector_type: PLASMID expression_system_plasmid: pCI-neo(Promega)

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Homo sapiens (taxid:9606)
	gene: F7 expression_system_common: Human expression_system_cell_line: 293 expression_system_organ: embryonic kidney expression_system_vector_type: PLASMID expression_system_plasmid: pCI-neo(Promega)

mol_id	organism_scientific	organism_common	expression_system
3	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: F3 expression_system_strain: BL21-DES3 expression_system_vector_type: PLASMID expression_system_plasmid: pET-21a(+) other_details: ESCHERICHIA COLI

Authors :

Katz, B.A., Luong, C., Ho, J.D., Somoza, J.R., Gjerstad, E., Tang, J., Williams, S.R., Verner, E., Mackman, R.L., Young, W.B., Sprengeler, P.A., Chan, H., Mortara, K., Janc, J.W., McGrath, M.E.

Keywords :

Ala190 uPA, S1 site, selectivity, conserved water displacement hydrogen bond deficit, trypsin, thrombin, hepsin, factor VIIa, BLOOD CLOTTING, hydrolase

Exp. method :

X-RAY DIFFRACTION ( 2.05 Å )

Citation :

Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).

Katz, B.A.,Luong, C.,Ho, J.D. et al.
(2004) J.Mol.Biol. 344 : 527 - 547

PubMed: 15522303
DOI: 10.1016/j.jmb.2004.09.032

Chain :

UniProt :

P08709 (FA7_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Ile bond in factor X to form factor Xa.	3.4.21.21	-
	-	-

Chain :	T
UniProt :	P13726 (TF_HUMAN)
Reaction :	-

PDB ID: 1O5D

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