PDB ID: 1O5C
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Structure summary
Code : | 1O5C PDBj RCSB PDB PDBe | ||||||||||||||||||||||||
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Header : | BLOOD CLOTTING, hydrolase | ||||||||||||||||||||||||
Title : | Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA) | ||||||||||||||||||||||||
Release Data : | 2004-09-21 | ||||||||||||||||||||||||
Compound : |
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Source : |
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Authors : | Katz, B.A., Luong, C., Ho, J.D., Somoza, J.R., Gjerstad, E., Tang, J., Williams, S.R., Verner, E., Mackman, R.L., Young, W.B., Sprengeler, P.A., Chan, H., Mortara, K., Janc, J.W., McGrath, M.E. | ||||||||||||||||||||||||
Keywords : | Ala190 uPA, S1 site, selectivity, conserved water displacement hydrogen bond deficit, trypsin, thrombin, hepsin, factor VIIa, BLOOD CLOTTING, hydrolase | ||||||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.63 Å ) | ||||||||||||||||||||||||
Citation : |
Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA)
Katz, B.A.,Luong, C.,Ho, J.D.
et al.
PubMed: 15522303 |
Reaction
Chain : | B | ||||||||
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UniProt : | P00749 (UROK_HUMAN) | ||||||||
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