Brand  (β version)

PDB ID: 1O46

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Ligands
Code Name Style Show Link
903 2-{4-[2-acetylamino-2-(1-biphenyl-4-ylmethyl-2-oxo-azepan-3-ylcarbamoyl)-ethyl]-2-methoxycarbonyl-phenyl}-2-fluoro-malonic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1O46   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU90395.
Release Data : 2004-02-17
Compound :
mol_id molecule chains synonym
1 PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC A P60-SRC, C-SRC
ec: 2.7.1.112
fragment: SH2 DOMAIN
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: SRC
expression_system_strain: BL21(DE3)
Authors : Lange, G., Loenze, P., Liesum, A.
Keywords : SH2 DOMAIN FRAGMENT APPROACH, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.

Lange, G.,Lesuisse, D.,Deprez, P.  et al.
(2003)  J.Med.Chem.  46 : 5184 - 5195

PubMed: 14613321
DOI: 10.1021/jm020970s

Reaction

Chain : A
UniProt : P12931 (SRC_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.2 PROSITE-ProRule:PRU10028, PubMed:14632929, PubMed:19307596, PubMed:21036157, PubMed:35927303, PubMed:7929427, PubMed:8759729, PubMed:9571170
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[Isoform 1]
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 		2.7.10.2 UniProtKB:Q9WUD9
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[Isoform 2]
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 		2.7.10.2 UniProtKB:Q9WUD9
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[Isoform 3]
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 		2.7.10.2 UniProtKB:Q9WUD9
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