Brand  (β version)

PDB ID: 1O2R

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
CL Chloride ion PoSSuM
CR9 2-{5-[amino(iminio)methyl]-6-fluoro-1h-benzimidazol-2-yl}-6-[(2-methylcyclohexyl)oxy]benzenolate PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 1O2R   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
Release Data : 2003-09-02
Compound :
mol_id molecule chains
1 BETA-TRYPSIN A
ec: 3.4.21.4
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Cattle
organ: PANCREAS
Authors : Katz, B.A., Elrod, K., Verner, E., Mackman, R.L., Luong, C., Shrader, W.D., Sendzik, M., Spencer, J.R., Sprengeler, P.A., Kolesnikov, A., Tai, V.W., Hui, H.C., Breitenbucher, J.G., Allen, D., Janc, J.W.
Keywords : serine protease, short hydrogen bond, inhibition mechanism, shift of pKa, trypsin, thrombin, urokinase, factor Xa, hydrolase
Exp. method : X-RAY DIFFRACTION ( 1.45 Å )
Citation :

Elaborate manifold of short hydrogen bond arrays mediating binding of active site-directed serine protease inhibitors.

Katz, B.A.,Elrod, K.,Verner, E.  et al.
(2003)  J.Mol.Biol.  329 : 93 - 120

PubMed: 12742021
DOI: 10.1016/S0022-2836(03)00399-1

Reaction

Chain : A
UniProt : P00760 (TRY1_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa. 3.4.21.4 -
-
Cofactor: Evidence: Note:
Ca(2+) - Binds 1 Ca(2+) ion per subunit.