Brand  (β version)

PDB ID: 1O28

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Ligands
Code Name Style Show Link
EPE 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid PoSSuM
PGE Triethylene glycol PoSSuM
UFP 5-fluoro-2'-deoxyuridine-5'-monophosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1O28   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima with FdUMP at 2.1 A resolution
Release Data : 2003-06-24
Compound :
mol_id molecule chains synonym
1 Thymidylate synthase thyX A,B,C,D TS, TSase, thymidylate synthase complementing protein
ec: 2.1.1.-
Source :
mol_id organism_scientific expression_system
1 Thermotoga maritima  (taxid:2336) Escherichia coli  (taxid:562)
gene: TM0449
expression_system_vector_type: Plasmid
Authors : Mathews, I.I., Deacon, A.M., Canaves, J.M., McMullan, D., Lesley, S.A., Agarwalla, S., Kuhn, P., Joint Center for Structural Genomics (JCSG)
Keywords : TM0449, THYMIDYLATE SYNTHASE COMPLEMENTING PROTEIN, STRUCTURAL GENOMICS, JCSG, Joint Center for Structural Genomics, PSI, Protein Structure Initiative, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein

Mathews, I.I.,Deacon, A.M.,Canaves, J.M.  et al.
(2003)  Structure  11 : 677 - 690

PubMed: 12791256
DOI: 10.1016/S0969-2126(03)00097-2

Reaction

Chain : A, B, C, D
UniProt : Q9WYT0 (THYX_THEMA)
Reaction: EC: Evidence:
Physiological Direction:
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+) 2.1.1.148 PubMed:12791256, PubMed:19370033
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dUMP + formaldehyde + H(+) + NADPH = dTMP + H2O + NADP(+) - PubMed:34315871
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