Brand  (β version)

PDB ID: 1O02

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Ligands
Code Name Style Show Link
MG Magnesium ion PoSSuM
NA Sodium ion PoSSuM
GAI Guanidine PoSSuM
EDO 1,2-ethanediol PoSSuM
NAI 1,4-dihydronicotinamide adenine dinucleotide PoSSuM
Non-standard Residues
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Structure summary

Code : 1O02   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Human mitochondrial aldehyde dehydrogenase complexed with NADH in the presence of Mg2+
Release Data : 2003-06-24
Compound :
mol_id molecule chains synonym
1 Aldehyde dehydrogenase A,B,C,D,E,F,G,H ALDH class 2, ALDHI, ALDH-E2
ec: 1.2.1.3
fragment: Complete mature sequence (does not contain mitochondrial leader sequence).
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21  (taxid:511693)
gene: ALDH2 OR ALDM
expression_system_strain: BL21
expression_system_vector_type: plasmid
expression_system_plasmid: PET7-7
Authors : Perez-Miller, S.J., Hurley, T.D.
Keywords : ALDH, NAD, NADH, isomerization, Oxidoreductase
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase

Perez-Miller, S.J.,Hurley, T.D.
(2003)  Biochemistry  42 : 7100 - 7109

PubMed: 12795606
DOI: 10.1021/bi034182w

Reaction

Chain : A, B, C, D, E, F, G, H
UniProt : P05091 (ALDH2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH 1.2.1.3 -
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