Brand  (β version)

PDB ID: 1NZ7

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Ligands
Code Name Style Show Link
901 2-[(4-{2-acetylamino-2-[4-(1-carboxy-3-methylsulfanyl-propylcarbamoyl)-butylcarbamoyl]-ethyl}-2-ethyl-phenyl)-oxalyl-am ino]-benzoic acid PoSSuM
Non-standard Residues
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Structure summary

Code : 1NZ7   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : POTENT, SELECTIVE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B USING A SECOND PHOSPHOTYROSINE BINDING SITE, complexed with compound 19.
Release Data : 2003-05-20
Compound :
mol_id molecule chains synonym
1 Protein-tyrosine phosphatase, non-receptor type 1 A Protein-tyrosine phosphatase 1B, PTP-1B
ec: 3.1.3.48
fragment: PTP1B catalytic domain
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PTPN1 OR PTP1B
expression_system_strain: BL21(De3)/pTPASE 1b
expression_system_vector_type: PLASMID
expression_system_plasmid: pT7-7
Authors : Xin, Z., Oost, T.K., Abad-Zapatero, C., Hajduk, P.J., Pei, Z., Szczepankiewicz, B.G., Hutchins, C.W., Ballaron, S.J., Stashko, M.A., Lubben, T., Trevillyan, J.M., Jirousek, M.R., Liu, G.
Keywords : PROTEIN TYROSINE PHOSPHATASE FOLD, OXAMIC ACID INHIBITOR BOUND TO P-LOOP, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Potent, Selective Inhibitors of Protein Tyrosine Phosphatase 1B

Xin, Z.,Oost, T.K.,Abad-Zapatero, C.  et al.
(2003)  BIOORG.MED.CHEM.LETT.  13 : 1887 - 1890

PubMed: 12749891
DOI: 10.1016/S0960-894X(03)00302-0

Reaction

Chain : A
UniProt : P18031 (PTN1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate 3.1.3.48 PROSITE- ProRule:PRU10044
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