Brand  (β version)

PDB ID: 1NWL

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Ligands
Code Name Style Show Link
964 3-(4-{2-[2-(2-bromo-acetylamino)-ethyldisulfanyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-pyrazine-2-carboxylic acid PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Structure summary

Code : 1NWL   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of the PTP1B complexed with SP7343-SP7964, a pTyr mimetic
Release Data : 2003-04-01
Compound :
mol_id molecule chains synonym
1 protein-tyrosine phosphatase, non-receptor type 1 A PTP-1B; Protein-tyrosine phosphatase 1B; protein tyrosine phosphatase, placental
ec: 3.1.3.48
fragment: residues 1-298
mutation: R47C
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PTPN1
Authors : Erlanson, D.A., McDowell, R.S., He, M.M., Randal, M., Simmons, R.L., Kung, J., Waight, A., Hansen, S.
Keywords : protein-small molecule inhibitor complex, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Discovery of a New Phosphotyrosine Mimetic for PTP1B Using Breakaway Tethering

Erlanson, D.A.,McDowell, R.S.,He, M.M.  et al.
(2003)  J.Am.Chem.Soc.  125 : 5602 - 5603

PubMed: 12733877
DOI: 10.1021/ja034440c

Reaction

Chain : A
UniProt : P18031 (PTN1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate 3.1.3.48 PROSITE- ProRule:PRU10044
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