Brand  (β version)

PDB ID: 1NWE

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Ligands
Code Name Style Show Link
FG1 N-[4-(2-{2-[3-(2-bromo-acetylamino)-propionylamino]-3-hydroxy-propionylamino}-ethyl)-phenyl]-oxalamic acid PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 1NWE   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Ptp1B R47C Modified at C47 with N-[4-(2-{2-[3-(2-Bromo-acetylamino)-propionylamino]-3-hydroxy-propionylamino}-ethyl)-phenyl]-oxalamic acid
Release Data : 2003-05-06
Compound :
mol_id molecule chains synonym
1 Protein-tyrosine phosphatase, non-receptor type 1 A Protein-tyrosine phosphatase 1B, PTP-1B
ec: 3.1.3.48
fragment: catalytic domain, residues 1-298
mutation: C32S, R47C, C92V
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21  (taxid:511693)
gene: PTPN1
expression_system_strain: BL21
expression_system_vector_type: plasmid
expression_system_plasmid: pRSET
Authors : Erlanson, D.A., McDowell, R.S., He, M.M., Randal, M., Simmons, R.L., Kung, J., Waight, A., Hansen, S.K.
Keywords : hydrolase, Acetylation, Phosphorylation, phospatase, phosphotyrosine mimetic
Exp. method : X-RAY DIFFRACTION ( 3.10 Å )
Citation :

Discovery of a New Phosphotyrosine Mimetic for PTP1B Using Breakaway Tethering

Erlanson, D.A.,McDowell, R.S.,He, M.M.  et al.
(2003)  J.Am.Chem.Soc.  125 : 5602 - 5603

PubMed: 12733877
DOI: 10.1021/ja034440c

Reaction

Chain : A
UniProt : P18031 (PTN1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate 3.1.3.48 PROSITE- ProRule:PRU10044
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