Brand  (β version)

PDB ID: 1NVF

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
CL Chloride ion PoSSuM
ADP Adenosine-5'-diphosphate PoSSuM
CRB [1r-(1alpha,3beta,4alpha,5beta)]-5-(phosphonomethyl)-1,3,4-trihydroxycyclohexane-1-carboxylic acid PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 1NVF   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Crystal structure of 3-dehydroquinate synthase (DHQS) in complex with ZN2+, ADP and carbaphosphonate
Release Data : 2003-03-18
Compound :
mol_id molecule chains synonym
1 3-DEHYDROQUINATE SYNTHASE A,B,C DHQS
ec: 4.2.3.4
Source :
mol_id organism_scientific expression_system
1 Emericella nidulans  (taxid:162425) Escherichia coli  (taxid:562)
gene: AROMA
expression_system_strain: GLW38 (AROB-)
expression_system_vector_type: plasmid
expression_system_vector: PTRC99A
expression_system_plasmid: PTR51
Authors : Nichols, C.E., Ren, J., Lamb, H.K., Hawkins, A.R., Stammers, D.K.
Keywords : SHIKIMATE PATHWAY, AROMATIC AMINO ACID BIOSYNTHESIS, DHQS, CLOSED FORM, FORM H, DOMAIN MOVEMENT, CYCLASE, LYASE
Exp. method : X-RAY DIFFRACTION ( 2.80 Å )
Citation :

Ligand-induced Conformational Changes and a Mechanism for Domain Closure in Aspergillus nidulans Dehydroquinate Synthase

Nichols, C.E.,Ren, J.,Lamb, H.K.  et al.
(2003)  J.MOL.BIOL.  327 : 129 - 144

PubMed: 12614613
DOI: 10.1016/S0022-2836(03)00086-X

Identification of many crystal forms of Aspergillus nidulans Dehydroquinate Synthase

Nichols, C.E.,Ren, J.,Lamb, H.  et al.
(2001)  Acta Crystallogr.,Sect.D  57 : 306 - 309

DOI: 10.1107/S0907444900019429

Reaction

Chain : A, B, C
UniProt : P07547 (ARO1_EMENI)
Reaction: EC: Evidence:
Physiological Direction:
7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3- dehydroquinate + phosphate 4.2.3.4 HAMAP-Rule:MF_03143
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3-dehydroquinate = 3-dehydroshikimate + H2O 4.2.1.10 HAMAP-Rule:MF_03143
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shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+) 1.1.1.25 HAMAP-Rule:MF_03143
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shikimate + ATP = 3-phosphoshikimate + ADP + H(+) 2.7.1.71 HAMAP-Rule:MF_03143
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3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1- carboxyvinyl)-3-phosphoshikimate + phosphate 2.5.1.19 HAMAP-Rule:MF_03143
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Cofactor: Evidence: Note:
Zn(2+) - Binds 2 Zn(2+) ions per subunit.