Brand  (β version)

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hetatm:

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information
centroid:
interaction residue:

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Ligands
Code Name Link
MG Magnesium ion
SR Strontium ion
Code : 1NUV
Header : RNA
Title : The Leadzyme Ribozyme Bound to Mg(H2O)6(II) and Sr(II) at 1.8 A resolution
Release Data : 2003-08-19
Compound :
mol_id molecule chains
1 5'-R(*CP*GP*GP*AP*CP*CP*GP*AP*GP*CP*CP*AP*G)-3' A,C,E,G
mol_id molecule chains
2 5'-R(*GP*CP*UP*GP*GP*GP*AP*GP*UP*CP*C)-3' B,D,F,H
Source :
mol_id organism_scientific
1
synthetic: yes
other_details: THIS RIBOZYME WAS MADE BY IN VITRO SELECTION, REPORTED BY PAN & UHLENBECK
mol_id organism_scientific
2
synthetic: yes
other_details: THIS RIBOZYME WAS MADE BY IN VITRO SELECTION, REPORTED BY PAN & UHLENBECK
Authors : Wedekind, J.E., Mckay, D.B.
Keywords : RIBOZYME, LEADZYME, LEAD-DEPENDENT CLEAVAGE, RNA, MG(H2O)6(II), BULGED NUCLEOTIDES, HYDRATED MAGNESIUM, SR(II), PSEUDOHELICAL PACKING, STICKY ENDS, ALTERNATE CONFORMATION, HOMOPURINE BASE PAIRS
Exp. method : X-RAY DIFFRACTION ( 1.81 Å )
Citation :

Crystal structure of the leadzyme at 1.8 A resolution: metal ion binding and the implications for catalytic mechanism and allo site ion regulation.

Wedekind, J.E.,McKay, D.B.
(2003)  BIOCHEMISTRY  42 : 9554 - 9563

PubMed: 12911297
DOI: 10.1021/bi0300783

CRYSTAL STRUCTURE OF A LEAD DEPENDENT RIBOZYME REVEALING METAL BINDING SITES RELEVANT TO CATALYSIS

Wedekind, J.E.,McKay, D.B.
(1999)  Nat.Struct.Biol.  6 : 261 - 268

DOI: 10.1038/6700