Het-PDB Navi2 (PDB: 1NU9)

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Ligands
Code	Name	Link
0ZJ	N-(sulfanylacetyl)-D-phenylalanyl-N-[(2s,3s)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide	PoSSuM
HG	Mercury (II) ion	PoSSuM
IMD	Imidazole	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1NU9

Code :

1NU9 PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Staphylocoagulase-Prethrombin-2 complex

Release Data :

2003-10-07

Compound :

mol_id	molecule	chains	synonym
1	Thrombin light and heavy chains	A,D	Coagulation factor II
	ec: 3.4.21.5

mol_id	molecule	chains
2	Staphylocoagulase	C,F
	fragment: UNP residues 1-281

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human
	tissue: blood

mol_id	organism_scientific	expression_system
2	Staphylococcus aureus (taxid:1280)	Escherichia coli (taxid:511693)
	expression_system_strain: BL21 expression_system_vector_type: plasmid expression_system_plasmid: pET30a

Authors :

Friedrich, R., Bode, W., Fuentes-Prior, P., Panizzi, P., Bock, P.E.

Keywords :

Thrombin non-proteolytic activator, endocarditis, hydrolase-hydrolase inhibitor complex, protein binding

Exp. method :

X-RAY DIFFRACTION ( 2.20 Å )

Citation :

Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation

Friedrich, R.,Panizzi, P.,Fuentes-Prior, P. et al.
(2003) NATURE 425 : 535 - 539

Chain :

A, D

UniProt :

P00734 (THRB_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.	3.4.21.5	-
	-	-

PDB ID: 1NU9