Het-PDB Navi2 (PDB: 1NRR)

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Ligands
Code	Name	Link
0G6	D-phenylalanyl-N-[(2s,3s)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide	PoSSuM

Download interaction data: 1NRR

Code :

Header :

Hydrolase/HYDROLASE INHIBITOR

Title :

Crystallographic structures of Thrombin complexed with Thrombin receptor peptides: Existence of expected and novel binding modes

Release Data :

1994-05-31

Compound :

mol_id	molecule	chains	synonym
1	Thrombin light chain	L	Coagulation factor II
	ec: 3.4.21.5 fragment: RESIDUES 328-363

mol_id	molecule	chains	synonym
2	Thrombin heavy chain	H	Coagulation factor II
	ec: 3.4.21.5 fragment: RESIDUES 364-622

mol_id	molecule	chains	synonym
3	Proteinase-activated receptor 1	R	Thrombin receptor, Coagulation factor II receptor
	fragment: UNP residues 43-60

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human

mol_id	organism_scientific	organism_common
3	Homo sapiens (taxid:9606)	Human

Authors :

Tulinsky, A., Mathews, I.I.

Keywords :

Hydrolase-Hydrolase Inhibitor complex, BLOOD CLOTTING

Exp. method :

X-RAY DIFFRACTION ( 2.4 Å )

Citation :

Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.

Mathews, I.I.,Padmanabhan, K.P.,Ganesh, V. et al.
(1994) Biochemistry 33 : 3266 - 3279

Refined Structure of the Hirudin-Thrombin Complex

Rydel, T.J.,Tulinsky, A.,Bode, W. et al.
(1991) J.Mol.Biol. 221 : 583

Structure of the Hirugen and Hirulog 1 Complexes of Alpha-Thrombin

Skrzypczak-Jankun, E.,Carperos, V.E.,Ravichandran, K.G. et al.
(1991) J.Mol.Biol. 221 : 1379

Chain :	H
UniProt :	P00734 (THRB_HUMAN)
Reaction :	Selective cleavage of Arg-\|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.

PDB ID: 1NRR