Brand  (β version)

PDB ID: 1NRR

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Ligands
Code Name Style Show Link
0G6 D-phenylalanyl-N-[(2s,3s)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1NRR   PDBj   RCSB PDB   PDBe
Header : Hydrolase/HYDROLASE INHIBITOR
Title : Crystallographic structures of Thrombin complexed with Thrombin receptor peptides: Existence of expected and novel binding modes
Release Data : 1994-05-31
Compound :
mol_id molecule chains synonym
1 Thrombin light chain L Coagulation factor II
ec: 3.4.21.5
fragment: RESIDUES 328-363
mol_id molecule chains synonym
2 Thrombin heavy chain H Coagulation factor II
ec: 3.4.21.5
fragment: RESIDUES 364-622
mol_id molecule chains synonym
3 Proteinase-activated receptor 1 R Thrombin receptor, Coagulation factor II receptor
fragment: UNP residues 43-60
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
3 Homo sapiens  (taxid:9606) Human
Authors : Tulinsky, A., Mathews, I.I.
Keywords : Hydrolase-Hydrolase Inhibitor complex, BLOOD CLOTTING
Exp. method : X-RAY DIFFRACTION ( 2.4 Å )
Citation :

Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.

Mathews, I.I.,Padmanabhan, K.P.,Ganesh, V.  et al.
(1994)  Biochemistry  33 : 3266 - 3279

PubMed: 8136362
DOI: 10.1021/bi00177a018

Refined Structure of the Hirudin-Thrombin Complex

Rydel, T.J.,Tulinsky, A.,Bode, W.  et al.
(1991)  J.Mol.Biol.  221 : 583

Structure of the Hirugen and Hirulog 1 Complexes of Alpha-Thrombin

Skrzypczak-Jankun, E.,Carperos, V.E.,Ravichandran, K.G.  et al.
(1991)  J.Mol.Biol.  221 : 1379

Reaction

Chain : H
UniProt : P00734 (THRB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. 3.4.21.5 -
-
Chain : R
UniProt : P25116 (PAR1_HUMAN)
Reaction : -