Brand  (β version)

PDB ID: 1NQ1

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Ligands
Code Name Style Show Link
4HY [4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]-acetic acid PoSSuM
ARS Arsenic PoSSuM
Non-standard Residues
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Structure summary

Code : 1NQ1   PDBj   RCSB PDB   PDBe
Header : HORMONE/GROWTH FACTOR RECEPTOR
Title : TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit Decreased Stability in the Nterminal LBD
Release Data : 2003-04-15
Compound :
mol_id molecule chains
1 Thyroid hormone receptor beta-1 A
fragment: LIGAND BINDING DOMAIN
mutation: R243Q
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: THRB OR NR1A2 OR ERBA2 OR THR1
expression_system_strain: BL21 DE3 PLYSS
expression_system_vector_type: PLASMID
expression_system_plasmid: PET28A
Authors : Huber, B.R., Desclozeaux, M., West, B.L., Cunha-Lima, S.T., Nguyen, H.T., Baxter, J.D., Ingraham, H.A., Fletterick, R.J.
Keywords : ALPHA HELICAL, LIGAND BINDING DOMAIN, HORMONE-GROWTH FACTOR RECEPTOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.9 Å )
Citation :

Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain

Huber, B.R.,Desclozeaux, M.,West, B.L.  et al.
(2003)  Mol.Endocrinol.  17 : 107 - 116

PubMed: 12511610
DOI: 10.1210/me.2002-0097

Reaction

Chain : A
UniProt : P10828 (THB_HUMAN)
Reaction : -