Brand  (β version)

PDB ID: 1NMX

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Ligands
Code Name Style Show Link
ADP Adenosine-5'-diphosphate PoSSuM
FDM 3'-fluoro-3'-deoxythymidine monophosphate PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1NMX   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of human thymidylate kinase with FLTMP and ADP
Release Data : 2003-03-18
Compound :
mol_id molecule chains
1 similar to THYMIDYLATE KINASE (DTMP KINASE) A
ec: 2.7.4.9
mutation: R200A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
Authors : Ostermann, N., Segura-Pena, D., Meier, C., Veit, T., Monnerjahn, M., Konrad, M., Lavie, A.
Keywords : thymidylate kinase, p-loop, fluorothymidine, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.7 Å )
Citation :

Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds

Ostermann, N.,Segura-Pena, D.,Meier, C.  et al.
(2003)  Biochemistry  42 : 2568 - 2577

PubMed: 12614151
DOI: 10.1021/bi027302t

Reaction

Chain : A
UniProt : P23919 (KTHY_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + dTMP = ADP + dTDP 2.7.4.9 PubMed:12614151, PubMed:2017365, PubMed:34918187, PubMed:8024690, PubMed:18469
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