Brand  (β version)

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Modified Residues
Code Name Link
ACE Acetyl group
CFT Trifluoromethane
DMH N4,n4-dimethyl-asparagine
DMK 3,3-dimethyl aspartic acid
Code : 1NKK
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : COMPLEX STRUCTURE OF HCMV PROTEASE AND A PEPTIDOMIMETIC INHIBITOR
Release Data : 2003-02-11
Compound :
mol_id molecule chains synonym
1 Capsid protein P40 A,B,C,D Protease, Capsid assembly protein
ec: 3.4.21.97
fragment: Assemblin
mutation: A143Q, E31R
mol_id molecule chains
2 Peptidomimetic inhibitor E,F,G,H
Source :
mol_id organism_scientific organism_common expression_system
1 Human herpesvirus 5  (taxid:10359) Human cytomegalovirus Escherichia coli  (taxid:562)
gene: UL80 OR APNG
mol_id organism_scientific
2
synthetic: yes
other_details: Residue peptide of the Peptidomimetic Inhibitor was chemically synthesized.
Authors : Khayat, R., Batra, R., Qian, C., Halmos, T., Bailey, M., Tong, L.
Keywords : PROTEASE, PEPTIDOMIMETIC INHIBITOR, INDUCED-FIT, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.60 Å )
Citation :

Structural and Biochemical Studies of Inhibitor Binding to Human Cytomegalovirus Protease

Khayat, R.,Batra, R.,Qian, C.  et al.
(2003)  Biochemistry  42 : 885 - 891

PubMed: 12549906
DOI: 10.1021/bi027045s

Chain : A, B, C, D
UniProt : P16753 (SCAF_HCMVA)
Reaction : Cleaves -Ala-|-Ser- and -Ala-|-Ala- bonds in the scaffold protein.