Brand  (β version)

PDB ID: 1NHX

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Ligands
Code Name Style Show Link
EDO 1,2-ethanediol PoSSuM
FTB N-{4-[1-(2-fluorobenzyl)-3-butyl-2,6-dioxo-2,3,6,7-tetrahydro-1h-purin-8-ylmethyl]-phenyl}-acetamide PoSSuM
MN Manganese (II) ion PoSSuM
NA Sodium ion PoSSuM
PEP Phosphoenolpyruvate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1NHX   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : PEPCK COMPLEX WITH A GTP-COMPETITIVE INHIBITOR
Release Data : 2003-09-30
Compound :
mol_id molecule chains synonym
1 PHOSPHOENOLPYRUVATE CARBOXYKINASE, CYTOSOLIC A Phosphoenolpyruvate carboxylase, PEPCK-C
ec: 4.1.1.32
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PCK1
Authors : Foley, L.H., Wang, P., Dunten, P., Ramsey, G., Gubler, M.-L., Wertheimer, S.J.
Keywords : GLUCONEOGENESIS, XANTHINE, INHIBITOR, LYASE
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

X-RAY STRUCTURES OF TWO XANTHINE INHIBITORS BOUND TO PEPCK and N-3 modifications of substituted 1,8-Dibenzylxanthines

FOLEY, L.H.,WANG, P.,DUNTEN, P.  et al.
(2003)  Bioorg.Med.Chem.Lett.  13 : 3871 - 3874

PubMed: 14552798
DOI: 10.1016/S0960-894X(03)00723-6

CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC PHOSPHOENOLPYRUVATE CARBOXYKINASE REVEALS A NEW GTP-BINDING SITE

DUNTEN, P.,BELUNIS, C.,CROWTHER, R.  et al.
(2002)  J.Mol.Biol.  316 : 257 - 264

DOI: 10.1006/jmbi.2001.5364

Reaction

Chain : A
UniProt : P35558 (PCKGC_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2 4.1.1.32 PubMed:24863970, PubMed:26971250, PubMed:28216384, PubMed:30193097, PubMed:32322062
right-to-left PubMed:30193097
L-seryl-[protein] + GTP = O-phospho-L-seryl-[protein] + GDP + H(+) - PubMed:32322062
left-to-right
Cofactor: Evidence: Note:
Mn(2+) ECO:0000269 | PubMed:11851336
ECO:0000269 | PubMed:14552798
ECO:0000269 | PubMed:17532214
Binds 1 Mn(2+) ion per subunit.