Het-PDB Navi2 (PDB: 1NH3)

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Ligands
Code	Name		Style	Show	Link

Non-standard Residues
Code	Name	Show
CAR	Cytosine arabinose-5'-phosphate
GNG	2'-deoxy-guanosine
PTR	O-phosphotyrosine
UBB	2',3'-dideoxy-uridine-5'-monophosphate

Glycosylation
Code	Name	Emphasize

Modification
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Download interaction data: 1NH3

Code :

1NH3 PDBj RCSB PDB PDBe

Header :

ISOMERASE/DNA

Title :

Human Topoisomerase I Ara-C Complex

Release Data :

2003-03-04

Compound :

mol_id	molecule	chains
1	5'-D(APAPAPAPAPGPAPCPUP(UBB))-3'	B

mol_id	molecule	chains
2	5'-D((GNG)PGPAPAPAPAPAPUPUPUPUPT)-3'	C

mol_id	molecule	chains
3	5'-D(APAPAPAPAPTPUPUPUPUPCP(CAR)PAPAPGPUPCPUPUPUPUPT)-3'	D

mol_id	molecule	chains
4	DNA topoisomerase I	A
	ec: 5.99.1.2 fragment: Core Subdomain, C-Terminal Domain

Source :

mol_id	organism_scientific
1
	synthetic: yes

mol_id	organism_scientific
2
	synthetic: yes

mol_id	organism_scientific
3
	synthetic: yes

mol_id	organism_scientific	organism_common	expression_system
4	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: TOP1 expression_system_common: Fall armyworm expression_system_cell_line: SF9 expression_system_vector_type: baculovirus

Authors :

Chrencik, J.E., Burgin, A.B., Pommier, Y., Stewart, L., Redinbo, M.R.

Keywords :

Ara-C, protein-DNA complex, DNA damage, isomerase, ISOMERASE-DNA COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 3.10 Å )

Citation :

Structural Impact of the Leukemia Drug 1-beta-D-Arabinofuranosylcytosine (Ara-C) on the Covalent Human Topoisomerase I-DNA Complex

Chrencik, J.E.,Burgin, A.B.,Pommier, Y. et al.
(2003) J.Biol.Chem. 278 : 12461 - 12466

PDB ID: 1NH3