Brand  (β version)

PDB ID: 1NEN

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Ligands
Code Name Style Show Link
OAA Oxaloacetate ion PoSSuM
CA Calcium ion PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
FES Fe2/s2 (inorganic) cluster PoSSuM
SF4 Iron/sulfur cluster PoSSuM
F3S Fe3-s4 cluster PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
DNT 2-[1-methylhexyl]-4,6-dinitrophenol PoSSuM
CDN Cardiolipin PoSSuM
EPH L-alpha-phosphatidyl-beta-oleoyl-gamma-palmitoyl-phosphatidylethanolamine PoSSuM
Non-standard Residues
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Structure summary

Code : 1NEN   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE/ELECTRON TRANSPORT
Title : Complex II (Succinate Dehydrogenase) From E. Coli with Dinitrophenol-17 inhibitor co-crystallized at the ubiquinone binding site
Release Data : 2003-02-25
Compound :
mol_id molecule chains
1 Succinate dehydrogenase flavoprotein subunit A
ec: 1.3.99.1, 1.3.5.1
mol_id molecule chains
2 Succinate dehydrogenase iron-sulfur protein B
ec: 1.3.99.1, 1.3.5.1
mol_id molecule chains
3 Succinate dehydrogenase cytochrome b-556 subunit C
mol_id molecule chains
4 Succinate dehydrogenase hydrophobic membrane anchor protein D
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: SDHA OR B0723 OR Z0877 OR ECS0748
expression_system_vector_type: plasmid
expression_system_plasmid: pfas
mol_id organism_scientific expression_system
2 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: SDHB OR B0724
expression_system_vector_type: plasmid
expression_system_plasmid: pfas
mol_id organism_scientific expression_system
3 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: SDHC OR CYBA OR B0721 OR Z0875 OR ECS0746
expression_system_vector_type: plasmid
expression_system_plasmid: pfas
mol_id organism_scientific expression_system
4 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: SDHD OR B0722
expression_system_vector_type: plasmid
expression_system_plasmid: pfas
Authors : Yankovskaya, V., Horsefield, R., Tornroth, S., Luna-Chavez, C., Miyoshi, H., Leger, C., Byrne, B., Cecchini, G., Iwata, S.
Keywords : membrane protein, respiratory complex, OXIDOREDUCTASE-ELECTRON TRANSPORT COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.9 Å )
Citation :

Architecture of succinate dehydrogenase and reactive oxygen species generation

Yankovskaya, V.,Horsefield, R.,Tornroth, S.  et al.
(2003)  Science  299 : 700 - 704

PubMed: 12560550
DOI: 10.1126/science.1079605

Reaction

Chain : A
UniProt : P0AC41 (SDHA_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
a quinone + succinate = fumarate + a quinol 1.3.5.1 PubMed:19710024
-
Cofactor: Evidence: Note:
FAD ECO:0000269 | PubMed:12560550
ECO:0000269 | PubMed:16407191
ECO:0000269 | PubMed:19710024
Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.
Chain : B
UniProt : P07014 (SDHB_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
a quinone + succinate = fumarate + a quinol 1.3.5.1 -
-
Cofactor: Evidence: Note:
[2Fe-2S] cluster - Binds 1 [2Fe-2S] cluster.
[3Fe-4S] cluster - Binds 1 [3Fe-4S] cluster.
[4Fe-4S] cluster - Binds 1 [4Fe-4S] cluster.
Chain : C
UniProt : P69054 (DHSC_ECOLI)
Reaction : -
Cofactor: Evidence: Note:
heme - The heme is bound between the two transmembrane subunits.
Chain : D
UniProt : P0AC44 (DHSD_ECOLI)
Reaction : -
Cofactor: Evidence: Note:
heme - The heme is bound between the two transmembrane subunits.