Brand  (β version)

PDB ID: 1NC3

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Ligands
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FMC (1s)-1-(7-amino-1h-pyrazolo[4,3-D]pyrimidin-3-yl)-1,4-anhydro-D-ribitol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1NC3   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of E. coli MTA/AdoHcy nucleosidase complexed with formycin A (FMA)
Release Data : 2003-03-25
Compound :
mol_id molecule chains synonym
1 MTA/SAH nucleosidase A,B P46, [Includes: 5'-methylthioadenosine nucleosidase EC 3.2.2.16, ; S-adenosylhomocysteine nucleosidase EC 3.2.2.9, ]
ec: 3.2.2.9
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli BL21  (taxid:511693)
gene: MTN OR PFS OR B0159 OR Z0170 OR ECS0163
expression_system_strain: BL21
expression_system_vector_type: plasmid
expression_system_vector: pPROEX HTa
Authors : Lee, J.E., Cornell, K.A., Riscoe, M.K., Howell, P.L.
Keywords : mixed alpha/beta dimer, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Structure of Escherichia coli 5'-methylthioadenosine/ S-adenosylhomocysteine nucleosidase inhibitor complexes provide insight into the conformational changes required for substrate binding and catalysis.

Lee, J.E.,Cornell, K.A.,Riscoe, M.K.  et al.
(2003)  J.Biol.Chem.  278 : 8761 - 8770

PubMed: 12496243
DOI: 10.1074/jbc.M210836200

Reaction

Chain : A, B
UniProt : P24247 (multiple entry names are found)
Reaction : -