Brand  (β version)

PDB ID: 1N95

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Ligands
Code Name Style Show Link
FTH 1-[2-(4-cyano-benzylamino)-3-(3-methyl-3h-imidazol-4-yl)-propionyl]-5-naphthalen-1-yl-1,2,3,6-tetrahydro-pyridine-4-carbonitrile PoSSuM
HFP Alpha-hydroxyfarnesylphosphonic acid PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1N95   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Aryl Tetrahydrophyridine Inhbitors of Farnesyltranferase: Glycine, Phenylalanine and Histidine Derivatives
Release Data : 2003-01-07
Compound :
mol_id molecule chains synonym
1 Protein farnesyltransferase alpha subunit A CAAX farnesyltransferase alpha subunit, RAS proteins prenyltransferase alpha, FTase-alpha
ec: 2.5.1.-
fragment: residue 55-369
mol_id molecule chains synonym
2 Protein farnesyltransferase beta subunit B CAAX farnesyltransferase beta subunit, RAS proteins prenyltransferase beta, FTase-beta
ec: 2.5.1.-
fragment: residue 22-423
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Norway rat Spodoptera frugiperda  (taxid:7108)
expression_system_common: Fall armyworm
expression_system_strain: Sf9
expression_system_vector_type: baculovirus
mol_id organism_scientific organism_common expression_system
2 Rattus norvegicus  (taxid:10116) Norway rat Spodoptera frugiperda  (taxid:7108)
expression_system_common: Fall armyworm
expression_system_strain: Sf9
expression_system_vector_type: baculovirus
Authors : Gwaltney II, S.L., O'Conner, S.J., Nelson, L.T., Sullivan, G.M., Imade, H., Wang, W., Hasvold, L., Li, Q., Cohen, J., Gu, W.Z.
Keywords : Farnesyltransferase, histidine tetrahydropyridine, Prenyltransferase, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.3 Å )
Citation :

Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives.

Gwaltney II, S.L.,O'Connor, S.J.,Nelson, L.T.  et al.
(2003)  Bioorg.Med.Chem.Lett.  13 : 1359 - 1362

PubMed: 12657282
DOI: 10.1016/S0960-894X(03)00095-7

Reaction

Chain : A
UniProt : Q04631 (FNTA_RAT)
Reaction: EC: Evidence:
Physiological Direction:
(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] 2.5.1.58 PubMed:12657282, PubMed:18844669, PubMed:19219049, PubMed:22963166
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geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein] 2.5.1.59 PubMed:14609943, PubMed:19219049
-
Chain : B
UniProt : Q02293 (FNTB_RAT)
Reaction: EC: Evidence:
Physiological Direction:
(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] 2.5.1.58 PubMed:10673434, PubMed:18844669, PubMed:19219049, PubMed:19246009, PubMed:22963166
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