Brand  (β version)

PDB ID: 1N5J

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Ligands
Code Name Style Show Link
MG Magnesium ion PoSSuM
SO4 Sulfate ion PoSSuM
TTP Thymidine-5'-triphosphate PoSSuM
TYD Thymidine-5'-diphosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1N5J   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE DIPHOSPHATE (TDP) AND THYMIDINE TRIPHOSPHATE (TTP) AT PH 5.4 (1.85 A RESOLUTION)
Release Data : 2003-04-15
Compound :
mol_id molecule chains
1 THYMIDYLATE KINASE A
ec: 2.7.4.9
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis  (taxid:1773) Escherichia coli  (taxid:562)
expression_system_vector_type: Plasmid
expression_system_plasmid: PET22B
Authors : Fioravanti, E., Haouz, A., Ursby, T., Munier-Lehmann, H., Delarue, M., Bourgeois, D.
Keywords : TRANSFERASE (ATP:TMP PHOSPHOTRANSFERASE), KINASE, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.85 Å )
Citation :

Mycobacterium tuberculosis Thymidylate Kinase: Structural Studies of Intermediates along the Reaction Pathway

Fioravanti, E.,Haouz, A.,Ursby, T.  et al.
(2003)  J.Mol.Biol.  327 : 1077 - 1092

PubMed: 12662932
DOI: 10.1016/S0022-2836(03)00202-X

Cryo-Photolysis of Caged Compounds: A Technique for Trapping Intermediate States in Protein Crystals

Ursby, T.,Weik, M.,Fioravanti, E.  et al.
(2002)  Acta Crystallogr.,Sect.D  58 : 607 - 614

DOI: 10.1107/S0907444902002135

X-Ray Structure of Tmp Kinase from Mycobacterium Tuberculosis Complexed with Tmp at 1.95 A Resolution

Li De La Sierra, I.,Munier-Lehmann, H.,Gilles, A.M.  et al.
(2001)  J.Mol.Biol.  311 : 87 - 100

DOI: 10.1006/jmbi.2001.4843

Crystallization and Preliminary X-Ray Analysis of the Thymidylate Kinase from Mycobacterium Tuberculosis

Li De La Sierra, I.,Munier-Lehmann, H.,Gilles, A.M.  et al.
(2000)  Acta Crystallogr.,Sect.D  56 : 226 - 228

DOI: 10.1107/S0907444999016212

Reaction

Chain : A
UniProt : O05891 (multiple entry names are found)
Reaction : -