Brand  (β version)

PDB ID: 1N3Z

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Ligands
Code Name Style Show Link
ADN Adenosine PoSSuM
U3P 3'-uridinemonophosphate PoSSuM
Non-standard Residues
Code Name Show
YCM S-(2-amino-2-oxoethyl)-L-cysteine
Glycosylation
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Structure summary

Code : 1N3Z   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of the [S-carboxyamidomethyl-Cys31, S-carboxyamidomethyl-Cys32] monomeric derivative of the bovine seminal ribonuclease in the liganded state
Release Data : 2003-08-26
Compound :
mol_id molecule chains synonym
1 Ribonuclease, seminal A Seminal RNase, Ribonuclease BS-1
ec: 3.1.27.5
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Cattle
Authors : Sica, F., Di Fiore, A., Zagari, A., Mazzarella, L.
Keywords : Protein-nucleotide complex, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.65 Å )
Citation :

The unswapped chain of bovine seminal ribonuclease: Crystal structure of the free and liganded monomeric derivative

Sica, F.,Di Fiore, A.,Zagari, A.  et al.
(2003)  Proteins  52 : 263 - 271

PubMed: 12833549
DOI: 10.1002/prot.10407

Bovine seminal ribonuclease: structure at 1.9 resolution

Mazzarella, L.,Capasso, S.,Demasi, D.  et al.
(1993)  Acta Crystallogr.,Sect.D  49 : 389 - 402

DOI: 10.1107/S0907444993003403

Swapping structural determinants of ribonucleases: an energetic analysis of the hinge peptide 16-22

Mazzarella, L.,Vitagliano, L.,Zagari, A.
(1995)  Proc.Natl.Acad.Sci.USA  92 : 3799 - 3803

Crystallization of multiple forms of bovine seminal ribonuclease in the liganded and unliganded state

Sica, F.,Adinolfi, S.,Berisio, R.  et al.
(1999)  J.CRYST.GROWTH  196 : 305 - 312

DOI: 10.1016/S0022-0248(98)00860-4

Binding of a substrate analog to a domain swapping protein: X-ray structure of the complex of bovine seminal ribonuclease with uridylyl(2',5')adenosine

Vitagliano, L.,Adinolfi, S.,Riccio, A.  et al.
(1998)  Protein Sci.  7 : 1691 - 1699

Coulombic effects of remote subsites on the active site of ribonuclease A

Fisher, B.M.,Schultz, L.W.,Raines, R.T.
(1998)  Biochemistry  37 : 17386 - 17401

DOI: 10.1021/bi981369s

Reaction

Chain : A
UniProt : P00669 (RNS_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
an [RNA] containing cytidine + H2O = an [RNA]-3'-cytidine-3'- phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA]. 4.6.1.18 PubMed:4664228
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an [RNA] containing uridine + H2O = an [RNA]-3'-uridine-3'- phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA]. 4.6.1.18 PubMed:4664228
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