Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

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Ligands
Code Name Link
K Potassium ion
MG Magnesium ion
AYD 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate
CIE 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester
DTT 2,3-dihydroxy-1,4-dithiobutane
FAD Flavin-adenine dinucleotide
TPP Thiamine diphosphate
Code : 1N0H
Header : LYASE
Title : Crystal Structure of Yeast Acetohydroxyacid Synthase in Complex with a Sulfonylurea Herbicide, Chlorimuron Ethyl
Release Data : 2003-01-07
Compound :
mol_id molecule chains synonym
1 Acetolactate synthase A,B Acetohydroxy-acid synthase, ALS, AHAS
ec: 4.1.3.18
fragment: MATURE CATALYTIC SUBUNIT
Source :
mol_id organism_scientific organism_common expression_system
1 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast Escherichia coli BL21(DE3)  (taxid:469008)
gene: ILV2
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: pET30c
Authors : Pang, S.S., Guddat, L.W., Duggleby, R.G.
Keywords : ACETOHYDROXYACID SYNTHASE, SULFONYLUREA, HERBICIDE INHIBITION, THIAMINE DIPHOSPHATE, LYASE
Exp. method : X-RAY DIFFRACTION ( 2.8 Å )
Citation :

Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase

Pang, S.S.,Guddat, L.W.,Duggleby, R.G.
(2003)  J.BIOL.CHEM.  278 : 7639 - 7644

PubMed: 14557277
DOI: 10.1074/jbc.M211648200

Chain : A, B
UniProt : P07342 (ILVB_YEAST)
Reaction : 2 pyruvate = 2-acetolactate + CO(2).