Brand  (β version)

PDB ID: 1MZC

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Ligands
Code Name Style Show Link
BNE 2-[3-(3-ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-[1-amino-1-(1-methyl-1h-imidizol-5-yl)-ethyl]-benzonitrile PoSSuM
FPP Farnesyl diphosphate PoSSuM
ZN Zinc ion PoSSuM
FRU Beta-D-fructofuranose PoSSuM
GLC Alpha-D-glucopyranose PoSSuM
: Polysaccharide
Non-standard Residues
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Structure summary

Code : 1MZC   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Co-Crystal Structure Of Human Farnesyltransferase With Farnesyldiphosphate and Inhibitor Compound 33a
Release Data : 2003-07-08
Compound :
mol_id molecule chains synonym
1 Protein Farnesyltransferase alpha Subunit A CAAX farnesyltransferase alpha subunit, RAS proteins prenyltransferase alpha, FTase-alpha
ec: 2.5.1.-
mol_id molecule chains synonym
2 Protein Farnesyltransferase beta Subunit B CAAX farnesyltransferase beta subunit, RAS proteins prenyltransferase beta, FTase-beta
ec: 2.5.1.-
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
Authors : deSolms, S.J., Ciccarone, T.M., MacTough, S.C., Shaw, A.W., Buser, C.A., Ellis-Hutchings, M., Fernandes, C., Hamilton, K.A., Huber, H.E., Kohl, N.E., Lobell, R.B., Robinson, R.G., Tsou, N.N., Walsh, E.S., Graham, S.L., Beese, L.S., Taylor, J.S.
Keywords : ALPHA-ALPHA BARREL, INHIBITOR, FTASE, PFTASE, FPP, CAAX, RAS, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Dual Protein Farnesyltransferase-Geranylgeranyltransferase-I Inhibitors as Potential Cancer Chemotherapeutic Agents.

DeSolms, S.J.,Ciccarone, T.M.,MacTough, S.C.  et al.
(2003)  J.Med.Chem.  46 : 2973 - 2984

PubMed: 12825937
DOI: 10.1021/jm020587n

Reaction

Chain : A
UniProt : P49354 (FNTA_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] 2.5.1.58 PubMed:12036349, PubMed:12825937, PubMed:16893176, PubMed:19246009, PubMed:8419339, PubMed:8494894
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geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein] 2.5.1.59 PubMed:16893176
-
Chain : B
UniProt : P49356 (FNTB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] 2.5.1.58 PubMed:12036349, PubMed:12825937, PubMed:16893176, PubMed:19246009, PubMed:8494894
-