Brand  (β version)

PDB ID: 1MQ2

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Ligands
Code Name Style Show Link
D5M 2'-deoxyadenosine-5'-monophosphate PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
Code Name Show
2DA 2',3'-dideoxyadenosine-5'-monophosphate
8OG 8-oxo-2'-deoxy-guanosine-5'-monophosphate
Glycosylation
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Modification
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Structure summary

Code : 1MQ2   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/DNA
Title : Human DNA Polymerase Beta Complexed With Gapped DNA Containing an 8-oxo-7,8-dihydro-Guanine and dAMP
Release Data : 2003-01-28
Compound :
mol_id molecule chains
1 5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3' T
mol_id molecule chains
2 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(2DA))-3' P
mol_id molecule chains
3 5'-D(P*GP*TP*CP*GP*G)-3' D
mol_id molecule chains
4 DNA POLYMERASE BETA A
ec: 2.7.7.7
Source :
mol_id organism_scientific
1
synthetic: yes
mol_id organism_scientific
2
synthetic: yes
mol_id organism_scientific
3
synthetic: yes
mol_id organism_scientific organism_common expression_system
4 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
Authors : Krahn, J.M., Beard, W.A., Miller, H., Grollman, A.P., Wilson, S.H.
Keywords : TRANSFERASE, DNA, TRANSFERASE-DNA COMPLEX
Exp. method : X-RAY DIFFRACTION ( 3.1 Å )
Citation :

Structure of DNA Polymerase beta with the Mutagenic DNA Lesion 8-oxodeoxyguanine Reveals Structural Insights into its Coding Potential

Krahn, J.M.,Beard, W.A.,Miller, H.  et al.
(2003)  Structure  11 : 121 - 127

PubMed: 12517346
DOI: 10.1016/S0969-2126(02)00930-9

Reaction

Chain : A
UniProt : P06746 (DPOLB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate 2.7.7.7 -
-
a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA = (2E,4S)- 4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-phospho-2'- deoxyribonucleoside-DNA + H(+) - PubMed:9572863, PubMed:9614142
-
2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'- deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3- dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'- deoxyribonucleoside-DNA + H(+) 4.2.99.18 PubMed:9614142
-
Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:9287163
Binds 2 magnesium ions per subunit.