Brand  (β version)

PDB ID: 1MJ3

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Ligands
Code Name Style Show Link
HXC Hexanoyl-coenzyme a PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1MJ3   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Crystal Structure Analysis of rat enoyl-CoA hydratase in complex with hexadienoyl-CoA
Release Data : 2002-09-24
Compound :
mol_id molecule chains synonym
1 ENOYL-COA HYDRATASE, MITOCHONDRIAL A,B,C,D,E,F Short chain enoyl-CoA hydratase, Enoyl-CoA hydratase 1, SCEH
ec: 4.2.1.17
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Norway rat Escherichia coli  (taxid:562)
Authors : Bell, A.F., Feng, Y., Hofstein, H.A., Parikh, S., Wu, J., Rudolph, M.J., Kisker, C., Tonge, P.J.
Keywords : Homohexamer, LYASE
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

Stereoselectivity of Enoyl-CoA Hydratase Results from Preferential Activation of One of Two Bound Substrate Conformers

Bell, A.F.,Feng, Y.,Hofstein, H.A.  et al.
(2002)  Chem.Biol.  9 : 1247 - 1255

PubMed: 12445775
DOI: 10.1016/S1074-5521(02)00263-6

Reaction

Chain : A, B, C, D, E, F
UniProt : P14604 (ECHM_RAT)
Reaction: EC: Evidence:
Physiological Direction:
a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O 4.2.1.17 PubMed:10074351, PubMed:7883013
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a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA 5.3.3.8 PubMed:10074351
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(3E)-hexenoyl-CoA = (2E)-hexenoyl-CoA - PubMed:10074351
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(3S)-3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O - PubMed:7883013
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3-hydroxyisovaleryl-CoA = 3-methyl-(2E)-butenoyl-CoA + H2O - UniProtKB:P30084
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3-hydroxypropanoyl-CoA = acryloyl-CoA + H2O - UniProtKB:P30084
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3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O - UniProtKB:P30084
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(2E)-2-methylpropenoyl-CoA + H2O = (S)-3-hydroxyisobutanoyl- CoA - UniProtKB:P30084
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(3S)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2O - PubMed:10074351
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(3S)-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2O - PubMed:10074351
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