Brand  (β version)

PDB ID: 1MHT

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Ligands
Code Name Style Show Link
SAH S-adenosyl-L-homocysteine PoSSuM
Non-standard Residues
Code Name Show
C36 5-methyl-5-fluoro-2'-deoxy-cytidine-5'-monophosphate
Glycosylation
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Modification
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Structure summary

Code : 1MHT   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/DNA
Title : COVALENT TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE, DNA AND S-ADENOSYL-L-HOMOCYSTEINE
Release Data : 1995-06-03
Compound :
mol_id molecule chains
1 DNA (5'-D(P*GP*AP*TP*AP*GP*(C36)P*GP*CP*TP*AP*TP*C)-3') B
mol_id molecule chains
2 DNA (5'-D(*TP*GP*AP*TP*AP*GP*(C36)P*GP*CP*TP*AP*TP*C)-3') C
mol_id molecule chains
3 PROTEIN (HHAI METHYLTRANSFERASE) A
ec: 2.1.1.73
Source :
mol_id organism_scientific
1
synthetic: yes
mol_id organism_scientific
2
synthetic: yes
mol_id organism_scientific
3 Haemophilus haemolyticus  (taxid:726)
Authors : Cheng, X.
Keywords : PROTEIN-DNA COMPLEX, DOUBLE HELIX, OVERHANGING BASE, FLIPPED-OUT BASE, MODIFIED, TRANSFERASE-DNA COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.60 Å )
Citation :

HhaI methyltransferase flips its target base out of the DNA helix.

Klimasauskas, S.,Kumar, S.,Roberts, R.J.  et al.
(1994)  Cell(Cambridge,Mass.)  76 : 357 - 369

PubMed: 8293469
DOI: 10.1016/0092-8674(94)90342-5

Crystal Structure of the HhaI DNA Methyltransferase Complexed with S-Adenosyl-L-Methionine

Cheng, X.,Kumar, S.,Posfai, J.  et al.
(1993)  Cell(Cambridge,Mass.)  74 : 299

Reaction

Chain : A
UniProt : P05102 (MTH1_HAEPH)
Reaction: EC: Evidence:
Physiological Direction:
a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5- methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine 2.1.1.37 PROSITE-ProRule:PRU10018, PubMed:7899082
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