Brand  (β version)

PDB ID: 1M9J

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Ligands
Code Name Style Show Link
CLW Chlorzoxazone PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1M9J   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : human endothelial nitric oxide synthase with chlorzoxazone bound
Release Data : 2002-08-14
Compound :
mol_id molecule chains synonym
1 endothelial Nitric-oxide synthase A,B EC-NOS, NOS, type III, NOSIII, Endothelial NOS, eNOS, Constitutive NOS, cNOS
ec: 1.14.13.39
fragment: oxygenase domain
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
Authors : Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Keywords : oxidoreductase
Exp. method : X-RAY DIFFRACTION ( 2.43 Å )
Citation :

Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency

Rosenfeld, R.J.,Garcin, E.D.,Panda, K.  et al.
(2002)  Biochemistry  41 : 13915 - 13925

PubMed: 12437348
DOI: 10.1021/bi026313j

Structure of nitric oxide synthase oxygenase dimer with pterin and substrate

Crane, B.R.,Arvai, A.S.,Ghosh, D.K.  et al.
(1998)  Science  279 : 2121 - 2126

DOI: 10.1126/science.279.5359.2121

Reaction

Chain : A, B
UniProt : P29474 (NOS3_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide 1.14.13.39 PubMed:1378832, PubMed:35772285
left-to-right PubMed:1378832