Het-PDB Navi2 (PDB: 1M7O)

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Ligands
Code	Name		Style	Show	Link
3PG	3-phosphoglyceric acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1M7O

Code :

1M7O PDBj RCSB PDB PDBe

Header :

ISOMERASE

Title :

Plasmodium Falciparum Triosephosphate isomerase (PfTIM) compled to substrate analog 3-phosphoglycerate (3PG)

Release Data :

2002-11-29

Compound :

mol_id	molecule	chains	synonym
1	Triosephosphate Isomerase	A,B	TIM; triose-phosphate isomerase; triose phosphate isomerase
	ec: 5.3.1.1

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Plasmodium falciparum (taxid:5833)	Malaria parasite P. falciparum	Escherichia coli (taxid:562)
	gene: TPI expression_system_strain: AA200 expression_system_vector_type: Plasmid expression_system_plasmid: ptrc 99A vector, called pARC

Authors :

Parthasarathy, S., Balaram, H., Balaram, P., Murthy, M.R.N.

Keywords :

TIM barrels; beta-alpha barrels; enzyme-inhibitor complex, ISOMERASE

Exp. method :

X-RAY DIFFRACTION ( 2.40 Å )

Citation :

Structures of Plasmodium falciparum triosephosphate isomerase complexed to substrate analogues: observation of the catalytic loop in the open conformation in the ligand-bound state.

Parthasarathy, S.,Balaram, H.,Balaram, P. et al.
(2002) Acta Crystallogr.,Sect.D 58 : 1992 - 2000

PubMed: 12454456
DOI: 10.1107/S0907444902015433

Triosephosphate Isomerase From Plasmodium Falciparum: Crystal Structure Proveides Insights into Antimalarial Drug Design.

Velankar, S.S.,Ray, S.S.,Gokle, R.S. et al.
(1997) Structure 5 : 751 - 761

DOI: 10.1016/S0969-2126(97)00230-X

PDB ID: 1M7O

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