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Ligands
Code Name Style Show Link
GOL Glycerol
SO4 Sulfate ion
Non-standard Residues
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CY4 S-butyryl-cystein
Glycosylation
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Modification
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Code : 1M4T   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Biosynthetic thiolase, Cys89 butyrylated
Release Data : 2002-11-29
Compound :
mol_id molecule chains synonym
1 Acetyl-CoA acetyltransferase A,B,C,D Acetoacetyl-CoA thiolase; biosynthetic thiolase
ec: 2.3.1.9
mutation: Cys89 butyrylated
Source :
mol_id organism_scientific expression_system
1 Zoogloea ramigera  (taxid:350) Escherichia coli  (taxid:562)
Authors : Kursula, P., Ojala, J., Lambeir, A.-M., Wierenga, R.K.
Keywords : thiolase fold, butyrylated intermediate, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.77 Å )
Citation :

The catalytic cycle of biosynthetic thiolase: A conformational journey of an acetyl group through four binding modes and two oxyanion holes

Kursula, P.,Ojala, J.,Lambeir, A.-M.  et al.
(2002)  Biochemistry  41 : 15543 - 15556

PubMed: 12501183
DOI: 10.1021/bi0266232

Chain : A, B, C, D
UniProt : P07097 (THIL_SHIZO)
Reaction: EC: Evidence:
Physiological Direction:
2 acetyl-CoA = acetoacetyl-CoA + CoA 2.3.1.9 PROSITE-ProRule:PRU10020
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