Brand  (β version)

PDB ID: 1LY4

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Ligands
Code Name Style Show Link
COQ 2,4-diamino-6-[N-(3',5'-dimethoxybenzyl)-N-methylamino]pyrido[2,3-D]pyrimidine PoSSuM
NAP Nadp nicotinamide-adenine-dinucleotide phosphate PoSSuM
Non-standard Residues
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Structure summary

Code : 1LY4   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Analysis of quinazoline and PYRIDO[2,3D]PYRIMIDINE N9-C10 reversed bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase
Release Data : 2002-08-28
Compound :
mol_id molecule chains
1 DIHYDROFOLATE REDUCTASE A
ec: 1.5.1.3
Source :
mol_id organism_scientific expression_system
1 Pneumocystis carinii  (taxid:4754) Escherichia coli  (taxid:562)
expression_system_strain: Bl21c
expression_system_vector_type: plasmid
expression_system_plasmid: pEt11b
Authors : Cody, V., Galitsky, N., Luft, J.R., Pangborn, W., Queener, S.F., Gangjee, A.
Keywords : pcDHFR, N9-C10 reversed bridge pyridopyrimidine antifolate, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

Analysis of quinazoline and pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase.

Cody, V.,Galitsky, N.,Luft, J.R.  et al.
(2002)  Acta Crystallogr.,Sect.D  58 : 1393 - 1399

PubMed: 12198294
DOI: 10.1107/S0907444902010442

The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution

Champness, J.N.,Achari, A.,Ballantine, S.P.  et al.
(1994)  Structure  2 : 915 - 924

Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+

Cody, V.,Galitsky, N.,Rak, D.  et al.
(1999)  Biochemistry  38 : 4303 - 4312

DOI: 10.1021/bi982728m

Reaction

Chain : A
UniProt : P16184 (DYR_PNECA)
Reaction: EC: Evidence:
Physiological Direction:
(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH 1.5.1.3 PROSITE- ProRule:PRU00660
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