Brand  (β version)

color scheme of protein:


interaction residue:

chain: Hide other chain(s)

Code Name Link
CA Calcium ion
YB Ytterbium (III) ion
DOT 3'anthraniloyl-2'-deoxy-adenosine-5'-triphosphate
Code : 1LVC
Header : LYASE
Title : Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin and 2' deoxy, 3' anthraniloyl ATP
Release Data : 2002-12-04
Compound :
mol_id molecule chains synonym
1 calmodulin-sensitive adenylate cyclase A,B,C ATP pyrophosphate-lyase, adenylyl cyclase, edema factor, ef, anthrax edema toxin adenylate cyclase component
fragment: c-terminal domain (residues 291-800)
mol_id molecule chains
2 calmodulin D,E,F
Source :
mol_id organism_scientific expression_system
1 Bacillus anthracis  (taxid:1392) Escherichia coli BL21  (taxid:511693)
expression_system_strain: BL21
expression_system_vector_type: Plasmid
expression_system_plasmid: pProEx
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli BL21  (taxid:511693)
expression_system_strain: BL21
expression_system_vector_type: Plasmid
expression_system_vector: CaM
Authors : Shen, Y., Lee, Y.-S., Soelaiman, S., Bergson, P., Lu, D., Chen, A., Beckingham, K., Grabarek, Z., Mrksich, M., Tang, W.-J.
Keywords : helical domain, protein-protein complex, LYASE
Exp. method : X-RAY DIFFRACTION ( 3.60 Å )
Citation :

Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins

Shen, Y.,Lee, Y.-S.,Soelaiman, S.  et al.
(2002)  Embo J.  21 : 6721 - 6732

PubMed: 12485993
DOI: 10.1093/emboj/cdf681

Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin

Drum, C.L.,Yan, S.Z.,Bard, J.  et al.
(2002)  Nature  415 : 396 - 402

DOI: 10.1038/415396a

Chain : A, B, C
UniProt : P40136 (CYAA_BACAN)
Reaction : ATP = 3',5'-cyclic AMP + diphosphate.
Chain : D, E, F
UniProt : P02593 (multiple entry names are found)
Reaction : -