Brand  (β version)

PDB ID: 1LV8

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Ligands
Code Name Style Show Link
9PP 2,6-diamino-(S)-9-[2-(phosphonomethoxy)propyl]purine PoSSuM
CA Calcium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1LV8   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of calf spleen purine nucleoside phosphorylase in a new space group with full trimer in the asymmetric unit
Release Data : 2003-09-02
Compound :
mol_id molecule chains
1 PURINE NUCLEOSIDE PHOSPHORYLASE A,B,C,D,E,F
ec: 2.4.2.1
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Cattle
tissue: SPLEEN
Authors : Bzowska, A., Koellner, G., Wielgus-Kutrowska, B., Stroh, A., Raszewski, G., Holy, A., Steiner, T., Frank, J.
Keywords : PNP, PURIE NUCLEOSIDE PHOSPHORYLASE, PENTOSYLTRANSFERASE, NE 2, 6-DIAMINOPURINE MULTISUBSTRATE ANALOGUE INHIBITOR, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Crystal structure of calf spleen purine nucleoside phosphorylase with two full trimers in the asymmetric unit: important implications for the mechanism of catalysis

Bzowska, A.,Koellner, G.,Wielgus-Kutrowska, B.  et al.
(2004)  J.Mol.Biol.  342 : 1015 - 1032

PubMed: 15342253
DOI: 10.1016/j.jmb.2004.07.017

Crystal Structure of Calf Spleen Purine Nucleoside in a Complex with Multisubstrate Analogue Inhibitor with 2,6-Diaminopurine Aglycone

Koellner, G.,Stroh, A.,Raszewski, G.  et al.
(2003)  NUCLEOSIDES NUCLEOTIDES NUCLEIC ACIDS  22 : 1699 - 1702

Crystals Structure of Calf Spleen Purine Nucleoside Phosphorylase in a Complex with Hypoxanthine at 2.15 A Resolution

Koellner, G.,Luic, M.,Shugar, D.  et al.
(1997)  J.Mol.Biol.  265 : 202 - 216

Calf Spleen Purine Nucleoside Phsophorylase: Crystal Structure of its Ternary Complex with an N(7)-Acycloguanosine Inhibitor and a Phosphate Anion

Luic, M.,Koellner, G.,Shugar, D.  et al.
(2001)  ACTA CRYSTALLOGR.,SECT.D  57 : 30 - 36

Reaction

Chain : A, B, C, D, E, F
UniProt : P55859 (PNPH_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine 2.4.2.1 UniProtKB:P00491
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guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine 2.4.2.1 UniProtKB:P00491
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2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1- phosphate + guanine 2.4.2.1 UniProtKB:P23492
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2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1- phosphate + hypoxanthine 2.4.2.1 UniProtKB:P23492
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