Het-PDB Navi2 (PDB: 1LTX)

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Ligands
Code	Name	Link
CL	Chloride ion	PoSSuM
FAR	Farnesyl	PoSSuM
ZN	Zinc ion	PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
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Modification
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Download interaction data: 1LTX

Code :

1LTX PDBj RCSB PDB PDBe

Header :

Transferase/Protein binding

Title :

Structure of Rab Escort Protein-1 in complex with Rab geranylgeranyl transferase and isoprenoid

Release Data :

2003-05-21

Compound :

mol_id	molecule	chains
1	RAB GERANYLGERANYLTRANSFERASE ALPHA SUBUNIT	A
	ec: 2.5.1.-

mol_id	molecule	chains	synonym
2	RAB GERANYLGERANYLTRANSFERASE BETA SUBUNIT	B	Geranylgeranyl transferase type II beta subunit
	ec: 2.5.1.-

mol_id	molecule	chains	synonym
3	Rab Escort Protein 1	R	Rab proteins geranylgeranyltransferase component A 1
	mutation: A473T, G483A, Q231K

mol_id	molecule	chains
4	AAAA	P

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Rattus norvegicus (taxid:10116)	Norway rat	Escherichia coli (taxid:562)
	expression_system_strain: BL21(DE3) RIL expression_system_vector_type: PLASMID expression_system_plasmid: pGATEV

mol_id	organism_scientific	organism_common	expression_system
2	Rattus norvegicus (taxid:10116)	Norway rat	Escherichia coli (taxid:562)
	expression_system_strain: BL21(DE3) RIL expression_system_vector_type: PLASMID expression_system_plasmid: pET30a

mol_id	organism_scientific	organism_common	expression_system
3	Rattus norvegicus (taxid:10116)	Norway rat	Spodoptera frugiperda (taxid:7108)
	expression_system_common: Fall armyworm expression_system_cell_line: SF21 expression_system_vector_type: baculovirus expression_system_vector: pBlueBAC

mol_id	organism_scientific
4
	synthetic: yes other_details: PUTATIVE PEPTIDE.

Authors :

Pylypenko, O., Rak, A., Reents, R., Niculae, A., Thoma, N.H., Waldmann, H., Schlichting, I., Goody, R.S., Alexandrov, K.

Keywords :

RAB PRENYLATION, PRENYLTRANSFERASE, LUCINE-RICH REPEATS, POST-TRANSLATIONAL MODIFICATION, Transferase-Protein binding COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 2.70 Å )

Citation :

Structure of Rab Escort Protein-1 in Complex with Rab Geranylgeranyltransferase

Pylypenko, O.,Rak, A.,Reents, R. et al.
(2003) Mol.Cell 11 : 483 - 494

PubMed: 12620235
DOI: 10.1016/S1097-2765(03)00044-3

Crystallization and Preliminary X-ray Diffraction Analysis of the Rab Escort Protein-1 in Complex with Rab Geranylgeranyltransferase

Rak, A.,Reents, R.,Pylypenko, O. et al.
(2001) J.STRUCT.BIOL. 136 : 158 - 161

DOI: 10.1006/jsbi.2001.4433

Chain :

UniProt :

Q08602 (PGTA_RAT)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]	2.5.1.60	PubMed:18756270, PubMed:19894725, PubMed:21520375, PubMed:22963166
	-

Chain :

UniProt :

Q08603 (PGTB2_RAT)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]	2.5.1.60	PubMed:18399557, PubMed:18756270, PubMed:19894725, PubMed:22480322, PubMed:22963166, PubMed:8505342
	-

Chain :	R
UniProt :	P37727 (RAE1_RAT)
Reaction :	-

PDB ID: 1LTX

Hetero Atom Contents

Structure summary

Reaction