Brand  (β version)

PDB ID: 1LTH

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Ligands
Code Name Style Show Link
NAD Nicotinamide-adenine-dinucleotide PoSSuM
FBP 1,6-di-O-phosphono-beta-D-fructofuranose PoSSuM
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Structure summary

Code : 1LTH   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : T AND R STATES IN THE CRYSTALS OF BACTERIAL L-LACTATE DEHYDROGENASE REVEAL THE MECHANISM FOR ALLOSTERIC CONTROL
Release Data : 1995-03-31
Compound :
mol_id molecule chains
1 L-LACTATE DEHYDROGENASE (T- AND R- STATE TETRAMER COMPLEX) T,R
ec: 1.1.1.27
Source :
mol_id organism_scientific expression_system
1 Bifidobacterium longum subsp. longum  (taxid:1679) Escherichia coli  (taxid:562)
strain: subsp. longum
gene: BIFIDOBACTERIUM LONGUM LDH GENE
expression_system_vector_type: BACTERIAL
expression_system_plasmid: PUBM9 (A DERIVATIVE OF PUC119)
Authors : Iwata, S., Ohta, T.
Keywords : OXIDOREDUCTASE, CHOH(D)-NAD(A), ALLOSTERIC ENZYME
Exp. method : X-RAY DIFFRACTION ( 2.5 Å )
Citation :

T and R states in the crystals of bacterial L-lactate dehydrogenase reveal the mechanism for allosteric control.

Iwata, S.,Kamata, K.,Yoshida, S.  et al.
(1994)  Nat.Struct.Biol.  1 : 176 - 185

PubMed: 7656036
DOI: 10.1038/nsb0394-176

A Regular 1:1 Complex of Two Allosteric States in the Single Crystal of L-Lactate Dehydrogenase from Bifidobacterium Longum

Iwata, S.,Yoshida, S.,Ohta, T.
(1994)  J.Mol.Biol.  236 : 958

Molecular Basis of Allosteric Activation of Bacterial L-Lactate Dehydrogenase

Iwata, S.,Ohta, T.
(1993)  J.Mol.Biol.  230 : 21

Mechanism of Allosteric Transition of Bacterial L-Lactate Dehydrogenase

Ohta, T.,Minowa, T.,Yokota, K.  et al.
(1992)  FARADAY DISC.CHEM.SOC  93 : 153

Crystallization of and Preliminary Crystallographic Data for Allosteric L-Lactate Dehydrogenase from Bifidobacterium Longum

Iwata, S.,Minowa, T.,Mikani, B.  et al.
(1989)  J.Biochem.(Tokyo)  106 : 558

Sequence and Characteristics of the Bifidobacterium Longum Gene Encoding L-Lactate Dehydrogenase and the Primary Structure of the Enzyme: A New Feature of the Allosteric Site

Minowa, T.,Iwata, S.,Sakai, H.  et al.
(1989)  Gene  85 : 161

Amino Acid Residues in the Allosteric Site of L-Lactate Dehydrogenase from Bifidobacterium Longum

Iwata, S.,Minowa, T.,Sakai, H.  et al.
(1989)  Agric.Biol.Chem.  53 : 3365

Reaction

Chain : T, R
UniProt : P19869
Reaction : -