Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
SM Samarium (III) ion
CIT Citric acid
Code : 1LT7
Header : TRANSFERASE
Title : Oxidized Homo sapiens betaine-homocysteine S-methyltransferase in complex with four Sm(III) ions
Release Data : 2002-09-11
Compound :
mol_id molecule chains synonym
1 BETAINE-HOMOCYSTEINE METHYLTRANSFERASE A,B BETAINE-HOMOCYSTEINE S-METHYLTRANSFERASE
ec: 2.1.1.5
mutation: P2A, C104A, C131A, C186A, C201A, C256A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
expression_system_strain: BL21-DE3
expression_system_vector_type: PLASMID
expression_system_plasmid: pTYB4
Authors : Evans, J.C., Huddler, D.P., Jiracek, J., Castro, C., Millian, N.S., Garrow, T.A., Ludwig, M.L.
Keywords : TRANSFERASE, homocysteine metabolism, homocysteinemia, thiol alkyl transfer
Exp. method : X-RAY DIFFRACTION ( 2.15 Å )
Citation :

Betaine-homocysteine methyltransferase: zinc in a distorted barrel.

Evans, J.C.,Huddler, D.P.,Jiracek, J.  et al.
(2002)  Structure  10 : 1159 - 1171

PubMed: 12220488
DOI: 10.1016/S0969-2126(02)00796-7

Chain : A, B
UniProt : Q93088 (BHMT1_HUMAN)
Reaction : Trimethylammonioacetate + L-homocysteine = dimethylglycine + L-methionine.