Het-PDB Navi2 (PDB: 1LT7)

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Ligands
Code	Name		Style	Show	Link
SM	Samarium (III) ion				PoSSuM
CIT	Citric acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1LT7

Code :

1LT7 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Oxidized Homo sapiens betaine-homocysteine S-methyltransferase in complex with four Sm(III) ions

Release Data :

2002-09-11

Compound :

mol_id	molecule	chains	synonym
1	BETAINE-HOMOCYSTEINE METHYLTRANSFERASE	A,B	BETAINE-HOMOCYSTEINE S-METHYLTRANSFERASE
	ec: 2.1.1.5 mutation: P2A, C104A, C131A, C186A, C201A, C256A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	expression_system_strain: BL21-DE3 expression_system_vector_type: PLASMID expression_system_plasmid: pTYB4

Authors :

Evans, J.C., Huddler, D.P., Jiracek, J., Castro, C., Millian, N.S., Garrow, T.A., Ludwig, M.L.

Keywords :

TRANSFERASE, homocysteine metabolism, homocysteinemia, thiol alkyl transfer

Exp. method :

X-RAY DIFFRACTION ( 2.15 Å )

Citation :

Betaine-homocysteine methyltransferase: zinc in a distorted barrel.

Evans, J.C.,Huddler, D.P.,Jiracek, J. et al.
(2002) Structure 10 : 1159 - 1171

Chain :

A, B

UniProt :

Q93088 (BHMT1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-homocysteine + glycine betaine = N,N-dimethylglycine + L- methionine	2.1.1.5	PubMed:10529246, PubMed:8798461, PubMed:9681996
	left-to-right	PubMed:10529246
Cofactor:	Evidence:	Note:
Zn(2+)	ECO:0000269 \| PubMed:10529246 ECO:0000269 \| PubMed:12220488 ECO:0000269 \| PubMed:9681996	Binds 1 zinc ion per subunit.

PDB ID: 1LT7