Brand  (β version)

PDB ID: 1LS3

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Ligands
Code Name Style Show Link
GLY Glycine PoSSuM
GOL Glycerol PoSSuM
PLP Pyridoxal-5'-phosphate PoSSuM
TGF 2-[4-(4-{4-[(2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydro-pteridin-6-ylmethyl)-amino]-benzoylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-pentanedioic acid PoSSuM
Non-standard Residues
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Structure summary

Code : 1LS3   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of the Complex between Rabbit Cytosolic Serine Hydroxymethyltransferase and TriGlu-5-formyl-tetrahydrofolate
Release Data : 2003-02-04
Compound :
mol_id molecule chains synonym
1 Serine Hydroxymethyltransferase A,B,C,D SERINE METHYLASE, GLYCINE HYDROXYMETHYLTRANSFERASE, SHMT
ec: 2.1.2.1
Source :
mol_id organism_scientific organism_common expression_system
1 Oryctolagus cuniculus  (taxid:9986) Rabbit Escherichia coli  (taxid:562)
expression_system_strain: HMS174(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: PET 22B(+)
Authors : Fu, T.F., Scarsdale, J.N., Kazanina, G., Schirch, V., Wright, H.T.
Keywords : asymmetric tetramer, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.70 Å )
Citation :

Location of the Pteroylpolyglutamate Binding Site on Rabbit Cytosolic Serine Hydroxymethyltransferase

Fu, T.F.,Scarsdale, J.N.,Kazanina, G.  et al.
(2003)  J.Biol.Chem.  278 : 2645 - 2653

PubMed: 12438316
DOI: 10.1074/jbc.M210649200

Reaction

Chain : A, B, C, D
UniProt : p07511 (GLYC_RABIT)
Reaction: EC: Evidence:
Physiological Direction:
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine 2.1.2.1 PubMed:1381582
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