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Code : 1LPZ   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 41.
Release Data : 2003-05-08
Compound :
mol_id molecule chains
1 Blood coagulation factor Xa A
ec: 3.4.21.6
fragment: light chain
mol_id molecule chains
2 Blood coagulation factor Xa B
ec: 3.4.21.6
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
Authors : Schreuder, H.A., Brachvogel, V., Liesum, A.
Keywords : Protein inhibitor complex, blood coagulation factor, serine proteinase, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Design and Quantitative Structure-Activity relationship of 3-amidinobenzyl-1H-indole-2-carboxamides as potent, nonchiral, and selective inhibitors of blood coagulation factor Xa

Matter, H.,Defossa, E.,Heinelt, U.  et al.
(2002)  J.Biol.Chem.  45 : 2749 - 2769

PubMed: 12061878
DOI: 10.1021/jm0111346

Chain : B
UniProt : P00742 (FA10_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin. 3.4.21.6 -
-