Brand  (β version)

PDB ID: 1LPC

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Ligands
Code Name Style Show Link
CMP Adenosine-3',5'-cyclic-monophosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1LPC   PDBj   RCSB PDB   PDBe
Header : ANTIVIRAL PROTEIN
Title : HIGH RESOLUTION STRUCTURE OF RECOMBINANT DIANTHIN ANTIVIRAL PROTEIN-POTENT ANTI-HIV AGENT (COMPLEX WITH CYCLIC AMP)
Release Data : 2004-05-11
Compound :
mol_id molecule chains synonym
1 DIANTHIN 30 A Antiviral protein DAP-30, rRNA N-glycosylase, rRNA N-glycosidase, Ribosome-inactivating protein
ec: 3.2.2.22
Source :
mol_id organism_scientific organism_common expression_system
1 Dianthus caryophyllus  (taxid:3570) Clove pink Escherichia coli  (taxid:562)
Authors : Kurinov, I.V., Rajamohan, F., Uckun, F.M.
Keywords : DIANTHIN ANTIVIRAL PROTEIN, RIBOSOME INACTIVATING PROTEIN, ANTI-HIV AGENT, HIV-1 INTEGRASE INHIBITOR, POLYNUCLEOTIDE:ADENOSINE GLYCOSIDASE, ANTIVIRAL PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.70 Å )
Citation :

High resolution X-ray structure and potent anti-HIV activity of recombinant dianthin antiviral protein.

Kurinov, I.V.,Rajamohan, F.,Uckun, F.M.
(2004)  Arzneimittelforschung  54 : 692 - 702

PubMed: 15553110

Reaction

Chain : A
UniProt : P24476 (RIP0_DIACA)
Reaction: EC: Evidence:
Physiological Direction:
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA. 3.2.2.22 UniProtKB:P84853
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