Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
0GJ L-alpha-glutamyl-N-{(1s)-4-{[amino(iminio)methyl]amino}-1-[(1s)-2-chloro-1-hydroxyethyl]butyl}glycinamide
Code : 1LMW
Header : Hydrolase/Hydrolase Inhibitor
Title : LMW U-PA Structure complexed with EGRCMK (GLU-GLY-ARG Chloromethyl Ketone)
Release Data : 1996-01-29
Compound :
mol_id molecule chains synonym
1 UROKINASE-TYPE PLASMINOGEN ACTIVATOR A,C LMW U-PA
ec: 3.4.21.73
mol_id molecule chains synonym
2 UROKINASE-TYPE PLASMINOGEN ACTIVATOR B,D LMW U-PA
ec: 3.4.21.73
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
Authors : Spraggon, G.S., Phillips, C., Nowak, U.K., Ponting, C.P., Saunders, D., Dobson, C.M., Stuart, D.I., Jones, E.Y.
Keywords : FIBRINOLYSIS, TRYPSIN-LIKE SERINE PROTEASE, SERINE PROTEASE, Hydrolase-Hydrolase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.5 Å )
Citation :

The crystal structure of the catalytic domain of human urokinase-type plasminogen activator.

Spraggon, G.,Phillips, C.,Nowak, U.K.  et al.
(1995)  Structure  3 : 681 - 691

PubMed: 8591045
DOI: 10.1016/S0969-2126(01)00203-9

Chain : B, D
UniProt : P00749 (UROK_HUMAN)
Reaction : Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.