Het-PDB Navi2 (PDB: 1LHC)

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Ligands
Code	Name		Style	Show	Link
DP7	Ac-(D)phe-pro-boroarg-oh				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1LHC

Code :

1LHC PDBj RCSB PDB PDBe

Header :

COMPLEX (SERINE PROTEASE/INHIBITOR)

Title :

HUMAN ALPHA-THROMBIN COMPLEXED WITH AC-(D)PHE-PRO-BOROARG-OH

Release Data :

1996-11-08

Compound :

mol_id	molecule	chains
1	ALPHA-THROMBIN	L
	ec: 3.4.21.5

mol_id	molecule	chains
2	ALPHA-THROMBIN	H
	ec: 3.4.21.5

mol_id	molecule	chains
3	HIRUDIN	I
	fragment: RESIDUES 54 - 65

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human
	organ: BLOOD tissue: BLOOD

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	organ: BLOOD tissue: BLOOD

mol_id	organism_scientific	organism_common
3	Hirudo medicinalis (taxid:6421)	Medicinal leech

Authors :

Weber, P.C., Lee, S.L., Lewandowski, F.A., Schadt, M.C., Chang, C.H., Kettner, C.A.

Keywords :

BLOOD COAGULATION, PLASMA, CALCIUM-BINDING, GLYCOPROTEIN, DUPLICATION, VITAMIN K, ZYMOGEN, GAMMA-CARBOXYGLUTAMIC ACID, ACUTE PHASE, LIVER, HYDROLASE, SERINE PROTEASE, KRINGLE, DISEASE MUTATION, COMPLEX (SERINE PROTEASE-INHIBITOR), COMPLEX (SERINE PROTEASE-INHIBITOR) complex

Exp. method :

X-RAY DIFFRACTION ( 1.95 Å )

Citation :

Kinetic and crystallographic studies of thrombin with Ac-(D)Phe-Pro-boroArg-OH and its lysine, amidine, homolysine, and ornithine analogs.

Weber, P.C.,Lee, S.L.,Lewandowski, F.A. et al.
(1995) Biochemistry 34 : 3750 - 3757

PubMed: 7893672
DOI: 10.1021/bi00011a033

PDB ID: 1LHC

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