Brand  (β version)

PDB ID: 1LH0

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Ligands
Code Name Style Show Link
MG Magnesium ion PoSSuM
ORO Orotic acid PoSSuM
PRP 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1LH0   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of Salmonella typhimurium OMP Synthase in Complex with MGPRPP and Orotate
Release Data : 2002-05-08
Compound :
mol_id molecule chains synonym
1 OMP synthase A,B OROTATE PHOSPHORIBOSYLTRANSFERASE
ec: 2.4.2.10
Source :
mol_id organism_scientific expression_system
1 Salmonella typhimurium  (taxid:602) Escherichia coli  (taxid:562)
expression_system_vector_type: plasmid
expression_system_plasmid: PCG13
Authors : Fedorov, A.A., Panneerselvam, K., Shi, W., Grubmeyer, C., Almo, S.C.
Keywords : loop closure, monomer closure, orotate phosphoribosyltransferase, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.0 Å )
Citation :

Structure of Salmonella typhimurium OMP Synthase in a Complete Substrate Complex.

Grubmeyer, C.,Hansen, M.R.,Fedorov, A.A.  et al.
(2012)  Biochemistry  51 : 4397 - 4405

PubMed: 22531064
DOI: 10.1021/bi300083p

Crystal structure of orotate phosphoribosyltransferase

Scapin, G.,Grubmeyer, C.,Sacchettini, J.C.
(1994)  Biochemistry  33 : 1287 - 1294

The crystal structure of the orotate phosphoribosyltransferase complexed with orotate and alpha-D-5-phosphoribosyl-1-pyrophosphate

Scapin, G.,Ozturk, D.H.,Grubmeyer, C.  et al.
(1995)  Biochemistry  34 : 10744 - 10754

Reaction

Chain : A, B
UniProt : P08870 (PYRE_SALTY)
Reaction: EC: Evidence:
Physiological Direction:
diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D- ribose 1-diphosphate + orotate 2.4.2.10 HAMAP- Rule:MF_01208
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